Skin Beautiful MD Highly Absorbable Berberine
This is one of our all time favorite supplements and we are excited to be launching a new formulation made in partnership with the top medical-grade supplement manufacturer in the US.
This supplement plays a key role in our Total Renew framework. It will help you look and feel great, and for $42, you can have a 2 month supply.
Berberine is a key component of ANY highly effective fat loss strategy, has been shown to be as effective as Metformin for diabetics, AND boosts total body collagen production.
It also has powerful antimicrobial, antiviral, and anti-parasitic effects.
And most interesting, Berberine has been shown to both clean out damaged cells, and trigger an increase in fibroblast production. Fibroblasts are critical cells that help trigger the production of collagen in your entire body.
It also has endless health benefits, which are documented on this page. This is something to take in the morning with your shake and extra fiber.
The following scientific explanation of the product was written by the medical team of our partner.
Skin Beautiful MD Highly Absorbable Berberine contains 400 mg of the plant alkaloid berberine (from Berberis aristata) for the primary purpose of supporting healthy blood sugar levels and enhancing insulin sensitivity.
As downstream effects of these main actions, berberine may also help improve dyslipidemia and other features of metabolic syndrome. Additionally, berberine has been shown to exhibit antimicrobial properties.
This particular Berberine is manufactured using an all-natural formulation that improves the absorption and delivery of berberine. This process uses a proprietary blend of MCT oils, non-soy derived lecithin, and vitamin E, without the use of potentially harmful surfactants.
Insulin and Blood Glucose Management
The most prominent of berberine’s clinical properties are its beneficial effects on insulin and blood glucose management. Berberine exerts its effects independently of the mechanisms of metformin and other common hypoglycemic agents, so the compound may be used alone or in conjunction with conventional pharmaceutical drugs.
In fact, berberine has been shown to be as effective as the popular drug metformin in lowering fasting blood glucose and hemoglobin A1c (HbA1c), LDL-C, triglycerides, and fasting insulin.1
When added to the existing medication regimens of patients with poorly controlled diabetes, berberine significantly reduced fasting and postprandial blood glucose, insulin, HbA1c and HOMA-IR. These changes were observed after just five weeks of berberine supplementation.1
In a separate study on newly diagnosed type-2 diabetics with dyslipidemia, berberine supplementation resulted in favorable changes to fasting blood glucose and insulin levels, triglycerides, uric acid, total cholesterol, HOMA-IR, LDL-C, HbA1c, and blood glucose and plasma insulin after a glucose loading test.2
Research supports berberine’s impressive effects on diabetes management and shows that it may be especially effective for diabetic patients with compromised liver function, for whom the potential adverse side-effects of conventional hypoglycemic drugs may not be an option.3 In study subjects with chronic hepatitis, berberine supplementation resulted in decreased enzyme markers for liver damage (ALT and AST), as well as decreased gamma-glutamyl transferase (GGT) in subjects without liver damage.3
There are multiple mechanisms behind berberine’s influence on blood glucose control and insulin sensitivity. In diabetics using insulin, the addition of berberine resulted in increased fasting and postprandial C-peptide levels, which suggests that long-term use of berberine might improve endogenous insulin secretion in patients who fail to respond, or who respond poorly, to oral hypoglycemic agents.11 In addition to increasing insulin secretion, berberine has been shown to increase insulin receptor expression in cultured human liver and muscle cells, which may improve insulin sensitivity.3
Moreover, contrary to thiazolidinedione drugs (TZDs), berberine “suppresses the differentiation of preadipocytes, and reduces the accumulation of lipid droplets.”3 This suggests berberine might be especially useful in cases of overweight or obese diabetics, where the potential for additional weight gain and edema associated with conventional pharmaceuticals would be undesirable.
Another biochemical mechanism behind berberine’s impressive effects is the inhibition of intestinal carbohydrate-digesting enzymes. Diabetic rats supplemented orally with berberine showed significant, dose-dependent decreases in intestinal disaccharidase activity.
Even in non-diabetic rats treated with berberine, two-hour area under the curve (AUC) blood glucose levels after sucrose and maltose loading were lower than those of untreated controls. Similar observations have been made in cultured human cell lines, which suggests berberine may be helpful for pre-diabetic patients and others presenting with early indicators of carbohydrate intolerance or metabolic syndrome that has not yet progressed to overt diabetes.4
Additional effects of berberine are achieved via inhibition of dipeptidyl peptidase IV (DPP IV). As DPP IV degrades incretin hormones—which stimulate post-prandial insulin secretion—increasing the half-life of incretins may help increase endogenous insulin secretion in response to a meal.5
Berberine also exerts blood glucose lowering effects by stimulating glycolysis via inhibition of mitochondrial glucose oxidation (specifically at complex I of the electron transport chain), and by increasing cellular glucose uptake independently of insulin.6
(The DPP IV inhibitor category of drugs is becoming more popular due to the efficacy of this mechanism in contributing to type-2 diabetes management.7)
Berberine increases phosphorylation of AMP-kinase (AMPK), which occurs naturally in response to physical exercise, fasting, and caloric restriction.8
In this sense, berberine may be thought of as a “calorie restriction mimetic,” which again mirrors the effects of metformin. In this sense, the combined effects of berberine in lowering blood glucose, increasing insulin sensitivity, and reducing mitochondrial oxygen consumption may have anti-aging properties.
Blood Lipids and Liver Health
Berberine has been shown to exert favorable effects on blood lipids and nonalcoholic fatty liver. Unlike statin drugs, berberine does not affect the complex cholesterol biosynthesis pathway, and therefore does not present the same undesirable side-effects. Berberine upregulates the expression of LDL receptor mRNA and increases liver expression of LDL receptors, allowing for more effective clearance of LDLs from the bloodstream.9,10
Diabetic, dyslipidemic rats supplemented with berberine showed favorable changes to total cholesterol, triglycerides, LDL-C, ApoB, and HDL-C. For some parameters, the effects were more powerful than those achieved with rosiglitazone and fenofibrate.11
In rats fed a fatty liver-inducing diet, supplemental berberine resulted in decreased total body weight, visceral adiposity, total cholesterol, LDL-C and triglycerides, while also reducing serum ALT and AST, which suggests a protective effect
for liver function. These markers were reduced compared to fatty liver rats not supplemented with berberine, but more notably, some of these parameters
were reduced to levels seen in a healthy control group fed a normal diet. Rats supplemented with berberine had lower liver weights and lower triglyceride content in the liver. Researchers concluded that berberine has direct effects upon the methylation status of genes involved in deposition of triglycerides in the liver.12
Berberine has also been demonstrated to reduce fibrosis in chemically induced liver damage.13,14 Because the liver is a key player in glycemic control, compounds that aid in blood sugar handling while simultaneously conferring significant protection to liver function may be powerful tools in the arsenal against metabolic syndrome.
Beyond its role as a powerful agent for blood sugar regulation, berberine has long been recognized as an antimicrobial, antiviral, and anti-parasitic compound. Berberine extracts
have demonstrated bactericidal effects against diarrhea-causing strains of Vibrio cholera and Escherichia coli, and anti-parasitic effects against Giardia lamblia, Entamoeba histolytica, and Trichomonas vaginalis.15 B
erberine may be as effective as the common antibiotic Flagyl against giardiasis.16 Other common organisms shown to be subject to the antimicrobial action of berberine include Candida, Chlamydia, Salmonella, Klebsiella, Clostridium, Shigella, and Cryptococcus.17
Tabeshpour, J., Imenshahidi, M., & Hosseinzadeh, H. (2017). A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome. Iranian Journal of Basic Medical Sciences, 20(5), 557–568. doi:10.22038/IJBMS.2017.8682
Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., & Sun, G. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipidemia and hypertension. Journal of Ethnopharmacology, 161, 69-81. doi: https://doi.org/10.1016/j.jep.2014.09.049
Pang, B., Zhao, L. H., Zhou, Q., Zhao, T. Y., Wang, H., Gu, C. J., & Tong, X. L. (2015). Application of berberine on treating type 2 diabetes mellitus. International Journal of Endocrinology, 2015, 1-12. doi:10.1155/2015/905749
Rahimi-Madiseh, M., Karimian, P., Kafeshani, M., & Rafieian-Kopaei, M. (2017). The effects of ethanol extract of Berberis vulgaris fruit on histopathological changes and biochemical markers of the liver damage in diabetic rats. Iranian Journal of Basic Medical Sciences, 20(5), 552–556. doi:10.22038/ IJBMS.2017.8681
Wang, Y., Zhou, L., Li, Y., Guo, L., Zhou, Z., Xie, H., ... Wang, B. (2017). The Effects of Berberine on Concanavalin A-Induced Autoimmune Hepatitis (AIH) in Mice and the Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase (AMPK) Pathway. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 23, 6150–6161. doi:10.12659/msm.907377
Suman, R. K., Borde, M. K., Mohanty, I. R., Maheshwari, U., & Deshmukh, Y. A. (2016). Myocardial Salvaging Effects of Berberine in Experimental Diabetes Co-Existing with Myocardial Infarction. Journal of Clinical and Diagnostic Research : JCDR, 10(3), FF13–FF18. doi:10.7860/JCDR/2016/15794.7459
Liu, L., Yu, Y. L., Yang, J. S., Li, Y., Liu, Y. W., Liang, Y.,...Wang, G.J. (2010). Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. Naunyn Schmiedebergs Archives of Pharmacology, 381(4):371-81. doi: 10.1007/s00210-010-0502-0
Al-Badri, G., Leggio, G. M., Musumeci, G., Marzagalli, R., Drago, F., & Castorina, A. (2018). Tackling dipeptidyl peptidase IV in neurological disorders. Neural Regeneration Research, 13(1), 26–34. doi:10.4103/1673-5374.224365
Wang, H., Zhu, C., Ying, Y., Luo, L., Huang, D., & Luo, Z. (2017). Metformin and berberine, two versatile drugs in treatment of common metabolic diseases. Oncotarget, 9(11), 10135–10146. doi:10.18632/ oncotarget.20807
Zhu, X., Bian, H., & Gao, X. (2016). The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease. Molecules (Basel, Switzerland), 21(10), 1-12. doi:10.3390/ molecules21101336
Yan, H. M., Xia, M. F., Wang, Y., Chang, X. X., Yao, X. Z., Rao, S. X., ... Gao, X. (2015). Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. PloS one, 10(8), e0134172. doi:10.1371/journal. pone.0134172
Sun, Y., Xia, M., Yan, H., Han, Y., Zhang, F., Hu, Z., ... Gao, X. (2018). Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21. British Journal of Pharmacology, 175(2), 374–387. doi:10.1111/bph.14079
Banach, M., Patti, A. M., Giglio, R. V., Cicero, A., Atanasov, A. G., Bajraktari, G.,... Rizzo, M. (2018). The role of nutraceuticals in statin intolerant patients. Journal of the American College of Cardiology, 72(1), 96-118. DOI: https://doi.org/10.1016/j.jacc.2018.04.040
Zhou, Y., Cao, S., Wang, Y., Xu, P., Yan, J., Bin, W.,...Kang, N. (2014). Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells. Fitoterapia, 92, 230-237. Doi: 10.1016/j.fitote.2013.11.010